摘要传统角膜移植术存在着供体来源缺乏、术后免疫排斥等问题.虽然很多地方已建立了眼库,但供体来源依然有限.因此,构造一种类似正常角膜结构的组织工程角膜、扩大角膜移植供体来源、满足患者需求成为治疗严重眼表疾病需要迫切解决的问题.本文对角膜上皮细胞的组织工程构建中采用的种子细胞进行归类,并介绍相关的重建方法及分析各种种子细胞在角膜上皮细胞组织工程中的优势及存在的问题,以期能为该领域的研究提供有益的探索方向.

abstractsThere remain several drawbacks including limited availability of donor corneas as well as recurrent allograft rejection and subsequent graft failure in conventional corneal transplantation.Although there have been established eye banks in many places,donor corneas are still limited.Therefore,it is significant to expand the sources of donor cornea,and construct the tissue engineered cornea in the treatment of severe ocular surface disease.We expound the classification of seed cells in the construction of tissue-engineered cornea and the repair of injured cornea. Furthermore,we analyze the advantage and disadvantage with regard to seed cells in the construction of tissue-engineered cornea,and supply some ideas for the research of tissue engineered cornea.