摘要在衰老过程中,玻璃体液化和玻璃体视网膜界面改变可诱发玻璃体后脱离(posterior vitreous detachment,PVD).不完全PVD及异常PVD通过玻璃体视网膜牵拉作用以及容量和化学转移可引起视网膜裂孔、孔源性视网膜脱离、视网膜前膜、黄斑水肿、年龄相关性黄斑变性、黄斑裂孔、玻璃体黄斑牵拉综合征等一系列并发症.为防止这些并发症进一步加重,减轻疾病恶化的风险,可以提前诱导完全性PVD或者采用玻璃体切除手术.目前药物性玻璃体融解术已进入临床前期研究,非酶试剂等非侵入性的治疗方法也在探索阶段.

abstractsIn the process of aging,the vitreous liquefaction and vitreoretinal interface changes can induce posterior vitreous detachment(PVD).Incomplete PVD and abnormal PVD can cause series of complications such as retinal tears,rhegmatogenous retinal detachment,epiretinal membrane,macular edema,age-related macular degeneration,macular hole,vitreomacular traction syndrome through vitreoretinal traction and capacity and chemical transfer.Inducing complete PVD or vitrectomy technology can prevent further aggravation of the disease and reduce the risk of disease progression.The pharmacologic vitreolysis has been studied pre-clinically.In addition,there are other non-invasive treatments such as non-enzyme reagent.