摘要他克莫司(Tacrolimus,又称FK506)是一种新型免疫抑制剂,主要用于肝脏移植、特应性皮炎等疾病.在眼部疾病中,他克莫司滴眼剂对免疫原性炎症性疾病(如春季角结膜炎、难治性过敏性结膜炎、自身免疫性结膜炎等免疫性角结膜炎)有效.随着研究的进展,他克莫司滴眼剂逐步应用于治疗移植物抗宿主病相关干眼、角膜移植排斥反应,他克莫司口服或玻璃体注射治疗难治性葡萄膜炎等.

abstractsTacrolimus （ FK506）,a novel immunosuppressant,has been used in liver transplantation and atopic dermatitis since it was discovered in 1984.In the field of eye diseases,eyedrops of tacrolimus has shown efficacy in immune-based inflammatory disorders （such as immune conjunctival and corneal diseases including vernal keratoconjunctivitis,refractory allergic conjunctivitis and autoimmune conjunctivitis）.As research developed,eyedrops of tacrolimus has been widely applied in graft-versus-host disease,corneal graft rejection,and oral or intravitreal injection of tacmlimus applied in refractory uveitis.