摘要肝再生磷酸酶(PRL)-3是一种蛋白质酪氨酸磷酸酶(PTP).近年来发现它能促进肿瘤细胞的增殖、黏附、侵袭及转移,诱导肿瘤的形成,尤其与结直肠癌的肝转移密切相关,是与肿瘤转移相关的"魅力"基因.了解PRL-3结构、功能以及其相关信号通路有助于阐明PRL-3在肿瘤转移中的调控机制.
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abstractsLiver regeneration phosphatase-3 (PRL-3)is one member of protein tyrosine phosphatase family involved in tumor metastasis, which can promote cell proliferation, adhesion, invasion and metastasis. PRL-3 is suggested as an attractive target for treatment of tumor metastasis,especially for treatment of liver metastasis of colorectal cancer. Our review focuses on recent advances about structure and function of PRL-3,its possible signal pathway involved in tumor metastasis.
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