摘要富含半胱氨酸的酸性分泌蛋白(SPARC)属于基质细胞蛋白家族,是一种具有多种功能的钙结合糖蛋白.在肿瘤中具有去黏附、抑制细胞增殖及与细胞外基质各成分之间相互作用的调节作用.在不同类型肿瘤中,SPARC表现不同的生物学作用,如在黑色素瘤、乳腺癌、食管癌等中与促进肿瘤发生发展有关,而在卵巢癌、宫颈癌、非小细胞肺癌等中却具有抑癌作用.

abstractsSecreted rotein acidicand rich in cysteine (SPARC), belonging to a family of matricellular proteins, is a multifunctional calcium-binding glycoprotein. In tumors, it functions as de-adhesion, antiproliferation, and regulation of extracellular matrix (ECM) interactions. But in different tumors,SPARC performances different biological effects, as in melanoma, breast cancer, esophageal cancer, etc, SPARC is associated with a highly aggressive tumor phenotype, while in ovarian cancer, cervical cancer, non-small cell lung cancer,SPARC may function as a tumor suppressor.