摘要DNA甲基化修饰与微小RNA(miRNA)在人类肿瘤的发生发展中均起重要作用.目前发现在肿瘤形成过程中miRNA启动子区可发生甲基化,也可通过调控DNA甲基化转移酶(DNMT)来调节DNA甲基化.通过对二者之间相互调控机制的研究,能为肿瘤的诊断治疗提供新的思路和方法.
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abstractsBoth DNA methylation and microRNAs(miRNA)play important roles in the development and progression of human cancer. Recently, it has been demonstrated that the promoter of miRNA can be methylated and DNA methylation can be regulated by miRNA through DNA methyltransferase. Research targeting this reciprocal regulatory mechanism may shed some light on the diagnosis and treatment of cancer.
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