摘要增强子是能够增强启动子转录活性的DNA顺式作用序列,生物信息学的诞生为其研究带来了极大的便利.利用增强子修饰的肿瘤特异性启动子使治疗或效应基因在特定的组织、细胞或器官中表达,实现对肿瘤靶向性治疗,是一种非常有意义的基因治疗途径.
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abstractsEnhancers are cis-acting elements of DNA which can enhance the transcription activity of promotors.Emerge of Bioinformatics brings great convenience for enhancers investigation.The utilization of tumor-specific promotors modified by enhancers to make the expression of theoretical gene or effector in specified organisms or cells,and to implement targeted therapy of tumor,is a significant and potential gene therapy method.
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