摘要重复细胞学检查、人乳头瘤病毒(HPV)检测或立即阴道镜为当前处理不明确意义不典型鳞状上皮细胞(ASCUS)最常用的方法.但这3种方法存在高漏诊率和误诊率、主观性强等不足,HPV持续感染、整合感染、宿主细胞基因不稳定及细胞恶性转变的生物学标记可更客观、有效地分流ASCUS.基于生物标记的多参数立体化检测可能成为分流异常细胞学结果的主要模式和手段.

abstractsRepeat cervical cytologic testing,human papillomavirus(HPV)testing and immediate colposcopy are currently the most general managements in women with atypical squamous cells of undetermined significance(ASCUS)result.However,the efficacy of these three methods is hampered by strong subjectivity,high false negative and positive rates.With the development of the aetiology of cervical cancer,there is good evidence that biomarkers for persistent HPV infection,HPV integration,instability of host genes and malignancy triage ASCUS more objectively and efficiently.The three-dimensional multiparameter biomarker-based detection may be the predominant method for the triage of women with abnormal cervical cancer screening result.