换一批
换一批摘要研究表明卵泡刺激素(FSH)在卵巢癌的发生发展中通过影响缺氧诱导因子-1(HIF-1)、血管内皮生长因子(VEGF)等因子的水平对血管生成起重要的调节作用。新近研究提示FSH-FSH受体(FSHR)可能参与了肺癌等性腺外实体瘤的血管生成过程。FSH与肿瘤血管生成密切相关，可能成为抗肿瘤血管生成的新靶点。
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abstractsRecent researches show that follicle stimulating hormone (FSH) plays an important regulatory role in the angiogenesis of ovarian cancer by influencing the level of some factors such as hypoxia induce factor-1 ( HIF-1 ) ,vascular endothelial growth factor (VEGF). Meanwhile, recent studies report that FSH and FSH receptor(FSHR) may also participate in the angiogenesis of other solid tumors like lung cancer. FSH is closely related to the tumor angiogenesis, which provides a novel therapeutic target for anti-angiogenesis thera-py.
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关键词
卵泡刺激素血管生成诱导剂抗药性,肿瘤Follicle stimulating hormoneAngiogenesis inducing agentsDrug resistance,neoplasm
主题词
肿瘤(Neoplasms)卵泡刺激素(Follicle Stimulating Hormone)血管(Blood Vessels)血管生成诱导剂(Angiogenesis Inducing Agents)抗药性(Drug Resistance)
分类号
R730.5
栏目名称
综述
DOI
10.3760/cma.j.issn.1673-422X.2011.08.004
发布时间
2011-11-24
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