摘要微小RNA (miRNA)是一类约22个核苷酸分子构成的非编码单链小RNA.miRNA能参与一系列重要的生物学活动,如早期胚胎与器官发育、细胞增殖与分化、细胞凋亡等.miRNA在肝细胞癌中表达异常,与肝癌发生发展和浸润转移密切相关.肝癌干细胞可能是肝癌复发和转移的根源,某些miRNA与肝癌干细胞的自我更新、多向分化及成瘤潜能存在紧密联系.调控miRNA在肝癌细胞或肝癌干细胞上的表达,可能是治疗肝细胞癌或防止治疗后复发的一种新途径.

abstractsMicroRNA (miRNA) is a class of small ( about 22 nueleotides),single-stranded and noncoding RNA molecule.It is demonstrated that miRNAs participate in a wide array of physiologic processes,such as the development of early embryos and organ,cell proliferation,differentiation and apoptosis.MiRNAwhich has abnormal expression in hepatocellular carcinoma is closely related to the occurrence,developmentand metastasis of liver cancer.Liver cancer stem cells may be the root of cancer recurrence and metastasis.Researches have provided clear evidence that some kinds of miRNAs are important regulators in serf-renewal and differentiation of cancer stem cells.Therefore,regulating the expression of miRNAs in hepatoma cells and liver cancer stem cells may be a new approach to treat hepatocellular carcinoma or prevent the recurrence after treatment.