换一批摘要基质金属蛋白酶(MMP)-2和MMP-9属于基质金属蛋白酶家族的明胶酶类,能够降解细胞外基质,在肿瘤细胞生长、分化、侵袭、转移、调节肿瘤血管生成及免疫监视中起到重要作用,因此与多种肿瘤的发生和发展密切相关.近几年,针对MMP-2和MMP-9的抑制剂与药物也受到广泛关注.
更多相关知识
abstractsMatrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are gelatinases of matrix metalloproteinase family,which play a crucial role in the cancer cell growth,differentiation,invasion,migration,the regulation of tumour angiogenesis and immune surveillance because of their ability to degrade extracellular matrix proteins.So they are significantly associated with development and progression of various tumors.In recent years,the inhibitors and drugs against MMP-2 and MMP-9 arouse wide concern.
More相关知识
医学主题词
肿瘤(Neoplasms)研究(Research)基质金属蛋白酶2(Matrix Metalloproteinase 2)基质金属蛋白酶9(Matrix Metalloproteinase 9)金属蛋白酶类(Metalloproteases)
栏目名称
DOI
10.3760/cma.j.issn.1673-422X.2012.011.007
发布时间
2013-01-26（万方平台首次上网日期，不代表论文的发表时间）
- 浏览0
- 被引23
- 下载0
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
