摘要组蛋白甲基转移酶通过影响组蛋白和DNA结合的紧密程度,影响异染色质形成、基因印记和基因转录调控.MLL基因作为组蛋白甲基转移酶编码基因,与肿瘤存在密切的关系.MLL基因家族中的MLL2在乳腺癌、大肠癌、淋巴瘤等恶性肿瘤中均异常高表达.肿瘤发生发展的过程中是否有MLL2的参与、参与的时间点及其发挥的作用均有待于进一步研究.

abstractsHistone methyltransferase modulates heterochromatin formation,genomic imprinting and genetic transcription by regulating the combination of histones and DNA.As encoding genes of histone methyltransferase,mixed-lineage leukemia (MLL) genes are found to have close relationship with tumors.Recently,MLL2,a member of this family,has been found highly expressed anomalously in breast cancer,colorectal cancer and lymphoma.Whether MLL2 participates in the progression of cancer,the time phase of its participation and its specific role are still remained to further study.