摘要不稳定编码区(CRD)是c-myc基因的影响因素之一.不稳定编码区结合蛋白(CRD-BP)与CRD结合可使CRD免受核酸内切酶攻击,阻止c-myc mRNA快速降解,增加c-myc蛋白含量.β-转导重复相容蛋白(β-TrCP)可对多个信号通路及细胞周期进行调控,影响细胞生长、分化、凋亡及肿瘤形成.CRD-BP高表达进而上调β-TCP,与结直肠癌的发生发展、转移侵袭等密切相关.

abstractsCoding region instability determinant (CRD) is one of the influence factors of oncogene c-myc.Coding region instability determinant-binding protein (CRD-BP) can connect with CRD in order to protect CRD from nuclease attack,prevent rapid degradation of c-myc mRNA,and increase c-myc protein content.Beta-transducin repeats-containing protein (β-TrCP) can affect cell growth,differentiation,apoptosis and oncogenesis by regulating multiple signaling pathways and cell cycle.The overexpression of CRD-BP can upregulate the expression of β-TrCP and both of them play important roles in the tumorigenesis,progression,metastasis and invasion of colorectal cancer.