摘要大多数恶性肿瘤患者存在血液高凝状态，易导致血栓形成，并与肿瘤转移复发密切相关。高凝状态形成机制与肿瘤、肿瘤相关治疗、合并症等相关。诊断指标主要有血小板、凝血与纤溶、P-选择素和溶酶体蛋白、血液流变学等。肿瘤高危血栓患者应使用低分子肝素，卧床肿瘤患者及肿瘤相关手术应预防血栓栓塞，肿瘤并发静脉血栓栓塞应用溶栓，伴有高凝状态的肿瘤患者应予化疗联合抗凝治疗。

abstractsThe majority of patients with malignant tumors have hypercoagulable state,which easily leads to thrombosis,and is closely related with recurrence of tumor metastasis.The formation mechanism of hypercoagulable state is related to tumor,tumor treatment,complications etc.The main diagnostic indicators are the platelet,cruor and fibrinolysis,P-selectin and lysosomal protein,blood rheology.Tumor patients with the high risk of thrombus should use low molecular weight heparin.Thromboembolism should be prevented in bedridden patients with tumor and tumor associated operation.Tumor patients with venous thromboembolism should be given thrombolytic treatment.Tumor patients with hypercoagulable state should be treated by antico-agulant therapy combined with chemotherapy.