摘要环状RNA是一种共价闭合环状分子,在环状RNA-微小RNA-信使RNA调控轴中充当微小RNA的海绵作用,可调控基因转录及蛋白质翻译.在妇科肿瘤中,环状RNA存在差异性表达,可影响细胞的增殖、迁移、侵袭,从而发挥抑癌或促癌作用.环状RNA的稳定性、丰富性、特异性及保守性使其有望成为妇科肿瘤预测、诊断及治疗的新靶点.

abstractsCircular RNAs (circRNAs) are a class of RNA which forms covalently closed loops.They act as microRNA (miRNA) sponge in the circRNA-miRNA-mRNA regulatory axis,regulating gene transcription and protein translation.CircRNAs are differently expressed in gynecological carcinoma.They can affect the proliferation,invasion and migration of gynecological tumor cells,playing a role in inhibiting or promoting cancer.CircRNAs are featured with characteristics of stabilities,abundance,specificity and conservative,making it a potential target for the prediction,diagnosis and treatment of gynecologic tumors.