摘要立体定向体部放疗(SBRT)可通过缺氧诱导因子-1α 及酸性鞘磷脂酶等生物因子有效杀伤肾癌细胞.较高生物剂量及单次照射的SBRT方案能够使晚期肾癌原发灶及转移灶得到更有效的局部控制,并且不良反应可耐受.SBRT与靶向药物联合治疗可增强肾癌对放疗的敏感性,SBRT与免疫药物联合治疗可通过远隔效应增强免疫反应.SBRT在晚期肾癌治疗相关的疗效,仍需进一步探索.

abstractsStereotactic body radiation therapy (SBRT)can effectively kill renal cancer cells by biologi-cal molecules such as hypoxia-inducible factor-1α and acid sphingomyelinase. SBRT regimen with higher biological dose and single irradiation can achieve more effective local control of primary and metastatic lesion of advanced renal cancer,and adverse reactions can be tolerated. Combination of SBRT and targeted drugs can increase the sensitivity of renal cancer to radiotherapy,and the combination of SBRT and immune drugs can enhance the immune response through the abscopal effect. The efficacy of SBRT in the treatment of advanced renal cancer remains to be explored.