摘要基底刚度是细胞外基质重要的力学参数之一。不同的基底刚度均可影响肿瘤细胞的增殖、运动和细胞表型等细胞生物学行为。基底刚度变化与肿瘤细胞的放化疗敏感性相关，可引起肿瘤干细胞特性的改变和某些信号通路激活或失活，主要涉及ABCG2蛋白和Akt/mTOR/Sox2信号通路。进一步探讨基底刚度在恶性肿瘤放化疗以及靶向治疗中的作用，有望为恶性肿瘤的临床治疗提供依据。

abstractsSubstrate stiffness is one of the important mechanical parameters of extracellular matrix. Different substrate stiffness will affect the proliferation, movement and phenotype of tumor cells. It is found that the change of substrate stiffness is also related to the chemotherapy and radiotherapy sensitivity of tumor cells. Substrate stiffness can cause changes in the characteristics of tumor stem cells, which are related to the activation or inactivation of some signaling pathways, mainly involving ABCG2 protein and Akt/mTOR/Sox2 signaling pathway. Further study on the role of substrate stiffness in radiotherapy, chemotherapy and targeted therapy of malignant tumor is expected to provide basis for the clinical treatment of malignant tumor.