摘要目的 研究消喘巴布剂的制备工艺、质量控制方法及对药效的影响.方法 采用水溶性高分子复合基质制备消喘巴布剂,进行黏着力试验,赋形性试验,含膏量试验,耐热、耐寒试验、毒性及药效初步试验.结果 消喘巴布剂载药量大,贴敷性能好,无致敏性与刺激性,药效显著.结论 实验所制巴布剂制备工艺合理可行,质量可控,是一种安全、有效的透皮给药系统.

abstractsObjective To study the influence of the preparation and quality control of Xiaochuan cataplasm on its drug action. Methods Xiaochuan cataplasm was prepared with hydrosoluble polymers matrix. A sequence of tests such as adhesive force test, recontour test, paste-content test, cold-resistance test, heat-resistance test, toxicity and pharmacodynamic action tests were performed on this drug. Results Xiaochuan cataplasm contains a sound volume of medicine, and shows good adhesive property, no sensibilization and stimulation, and notable drug action. Conclusion The results demonstrate that the preparation craft of Xiao-chuan cataplasm is reasonable and practicable., the quality is controllable and the method is a safe and effective transdermal drug delivery system.