摘要目的 观察复方玄驹胶囊联合醋酸甲泼尼松片、他莫昔芬片治疗肾阳虚型少精子症合并抗精子抗体阳性的疗效.方法 136例患者随机分为两组,对照组采用醋酸甲泼尼松片联合他莫昔芬片治疗,治疗组在对照组治疗基础上加用复方玄驹胶囊治疗,两组均治疗3个月为1个疗程.结果 治疗组总有效率为90.94%(61/67),女方妊娠11例(16.41%);对照组总有效率为63.07%(41/65),女方妊娠2例(3.08%),治疗组临床疗效优于对照组(P＜0.05).治疗后,两组精子密度和活力均显著提高(P＜0.05,P＜0.01),且治疗组提高幅度更大(P＜0.05).结论 复方玄驹胶囊联合醋酸甲泼尼松片、他莫昔芬片能提高治疗肾阳虚型少精子症合并抗精子抗体阳性所致男性不育的疗效.

abstractsObjective To observe the curative effect of the combined action of Compound Xuanju Capsule and Prednisone on oligospermatism and antisperm antibody due to yang deficiency of kidney. Methods 136 patients were randomly divided into two groups: a treated group, which was taken Compound Xuanju Capsule and Prednisone, and a control group, which was taken Prednisone and Tamoxifen Citrate Tablet. Both groups received a 3-month therapy. The conditions of semen and antisperm antibody between the two groups were observed before and after the treatment. Results The total effective rate of the treated group was 90.94% (61 in 67 cases), and in which 11 cases were pregnant (16.41%). While the total effective rate of the control group was 63.07% (41 in 65 cases), and in which 2 cases were pregnant (3.08%).The clinical efficacy of the treated group was better than that of the control group. (P＜0.05) After the treatment, sperm density and motility of two groups were both evidently increased, (P＜0.05, P＜0.01) and the treated group increased much more obviously (P＜0.05). Conclusion The combined action of Compound Xuanju Capsule and Prednisone can improve the curative effect on the treatment for male infertility from oligospermatism and antisperm antibody due to yang deficiency of kidney.