摘要目的 观察补气活血中药联合复方曲安奈德对口腔扁平苔藓患者血清白介素2(IL-2)、肿瘤坏死因子(TNF)水平的影响.方法 将43例口腔扁平苔藓患者按随机数字表法分为两组,对照组21例口服泼尼松片,30 mg/d,第2周减为15 mg/d,第3周减至5 mg/d,维持量4～8周,连用2个月.治疗组22例,根据病损的面积在患处黏膜基底部注射复方曲安奈德40 mg,用1.5ml注射用水溶解,与2%盐酸利多卡因注射液按照体积1∶1混合,在病损区基底部多点注射,1次/周,连用2个月;同时加服理气活血中药,1剂/d,早晚温服,连服2月.观察两组患者治疗前后的临床症状,并采用ELISA法测定血清IL-2及TNF水平,进行疗效评定.结果 治疗组治疗后血清IL-2(2.58±0.32)μg/L及TNF(156.45±13.67)ng/L水平与对照组治疗后、与同组治疗前比较,差异均有统计学意义(P均＜0.05).对照组治疗后血清IL-2(5.21±0.53)μg/L、TNF(205.02±15.75)ng/L水平与同组治疗前比较,差异有统计学意义(P＜0.05).治疗组总有效率为86.4%,对照组为66.7%,两组总有效率比较,差异有统计学意义(x2=3.321,P＜0.05).结论 采用补气活血中药联合复方曲安奈德治疗口腔扁平苔藓有效.

abstractsObjective To observe the effects of invigorating qi and promoting blood circulation drugs combined with compound triamcinolone acetonide on the interleukin 2 and tumor necrosis factor in patients with oral lichen planus. Methods 43 patients with oral lichen planus were randomly recurited into two groups by means of random number table.The control group was treated with prednisone orally, 30 mg/d, then reduced to IS mg/d at first two weeks, and further reduced to S mg/d at first three weeks. Maintained the dose for four to eight weeks. While the treatment group was treated with 40 mg compound triamcinolone acetonide at injury area by local injection,which was mixed with 2% lidocaine hydrochloride injection, once a week, continuous therapy for 2 months. Qi regulating and blood activating drugs were also added to the treatment group, with 150ml each time, once a day for 2 months. The clinical symptoms were observed, serum interleukin 2 and tumor necrosis factor were detected before and after the treatment. Results Compared with the control group, serum interleukin 2 and tumor necrosis factor in the treatment group decreased significantly after treatment [IL-2 (2.58± 0.32)ug/L, TNF(156.45+13.67)ng/L,P＜0.05]. Serum interleukin 2 and tumor necrosis factor decreased significantly after the treatment in the control group [IL-2(5.21±0.53) μg/L, TNF (205.02±15.75) ng/L,P＜ 0.05]. The total effective rate of the treatment group and the control group was 86.4% and 66.7% respectively, there was a significant difference (x2=3.321,P＜0.05).Conclusion Invigorating qi and promoting blood circulation drugs combined with compound triamcinolone acetonide on oral lichen planus was better than prednisone.