摘要目的：评价接骨七厘片联合带锁髓内针治疗胫腓骨骨折的临床疗效。方法选取80例胫腓骨骨折患者，按住院单双号分为2组，手术组39例以带锁髓内针治疗；联合药物组41例给予带锁髓内针联合接骨七厘片治疗。2组均治疗24周。评估2组围手术期参数、骨折愈合率、膝关节评分，评价临床疗效，并记录随访期间并发症发生情况。结果联合药物组住院时间[(14.43±2.47)d 比(21.63±3.16)d，t＝11.385]、骨折愈合时间[(5.22±1.05)月比(9.75±0.97)月，t＝20.016]均短于手术组(P＜0.01)；联合药物组骨折愈合率(92.7%比76.9%)高于对照组(χ2＝3.894，P＜0.05)。术后6个月，联合药物组疼痛度评分[(21.60±1.60)分比(19.50±1.90)分，t＝5.357]、活动度评分[(22.70±2.80)分比(18.70±2.40)分， t＝6.844]、稳定性评分[(23.50±2.40)分比(19.40±1.80)分，t＝8.610]、KSS 总评分[(89.20±9.30)分比(78.00±8.30)分，t＝5.673]均高于手术组(P＜0.01)。随访12个月，并发症发生率(7.3%比15.4%)与手术组比较，差异无统计学意义(χ2＝1.303，P＞0.05)。结论带锁髓内针联合接骨七厘片可促进骨折愈合，缩短住院时间，减轻术后疼痛。

abstractsObjective To explore the effict of Jiegu-Qili tablet combined with intramedullary interlocking nails in the treatment of the fracture of tibia and fibula. Methods A total of 80 patients with fracture of tibia and fibula were selected, and were divided into two groups according to odd and even number of hospitalization. The surgery group (39 patients) was given intramedullary interlocking nails, the surgery and drug group (41 patients) was given Jiegu-Qili tablet combined with intramedullary interlocking nails. The perioperative parameters, the rate of fracture healing, knee scores and complications were evaluated during 12 months. Results The hospitalization (14.43 ± 2.47 d vs. 21.63 ± 3.16 d, t=11.385, P<0.01) and fracture healing time (5.22 ± 1.05 m vs. 9.75 ± 0.97 m, t=20.016, P<0.05) of the surgery and drug group was shorter than that of the surgery group. The fracture healing rate of surgery and drug group (92.7%vs. 76.9%,χ2=3.894, P<0.05) was higher than that of the surgery group. After 6 months surgery, the pain, activity, stability and KSS scores (21.60 ± 1.60 vs. 19.50 ± 1.90, 22.7 ± 2.8 vs.18.70 ± 2.40, 23.50 ± 2.40 vs. 19.40 ± 1.80, 89.20 ± 9.30 vs. 78.00 ± 8.30) of the surgery and drug group were higher than that of the surgery group (P<0.05). There was no statistical significance on walking ability between two groups (21.40 ± 2.50 vs. 20.40 ± 2.20, P>0.05). During 12 months follow-up, there were no statistical significance on complications between two group (7.3%vs.15.4%,χ2=1.303, P>0.05). Conclusions In summary, the Jiegu-Qili tablet combined with intramedullary interlocking nails had a good therapeutic effect on the fracture of tibia and fibula. It could increase the speed of fracture healing, shorten the hospitalization, reduce the postoperative pain and improve the activity of patients.