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穴位神经电刺激联合酒石酸托特罗定片治疗女性膀胱过度活动症临床研究

Research on the curative effect of acupoint electrical nerve stimulation on the female patients with overactive bladder (air shower type)

摘要目的:评价穴位神经电刺激治疗女性膀胱过度活动症(overactive bladder,OAB)患者的疗效。方法将符合入选标准的70例OAB患者按随机数字表法分为2组,每组35例。对照组口服酒石酸托特罗定,治疗组在对照组基础上联用穴位神经电刺激治疗。2组均治疗20 d。记录治疗前后OAB患者症状评分(Overactive Bladder Symptom Score, OABSS)、生活质量评估表(Quality of Life Assessment Schedule,QOL)评分,观察排尿日志变化,评价临床疗效。结果治疗后,治疗组OABSS总分[(4.54±0.34)分比(6.62±1.43)分,t=8.251]、尿急症状评分[(1.26±0.32)分比(2.78±0.43)分,t=16.535]、QOL评分[(1.65±0.35)分比(2.25±0.32)分,t=7.377]均低于对照组(P<0.01)。治疗组24 h排尿次数[(7.03±1.21)次比(9.63±1.32)次,t=8.466]、24 h尿急次数[(0.24±0.12)次比(1.32±0.63)次,t=9.819]、72 h尿失禁次数[(0.38±0.14)次比(1.09±0.36)次,t=10.718]、夜尿次数[(0.46±0.22)次比(1.35±0.36)次,t=11.167]均低于对照组(P<0.01),每次排尿量[(241.38±20.32)ml 比(184.82±21.43)ml,t=12.300]高于对照组(P<0.01)。治疗组总有效率为97.1%(33/34)、对照组为79.4(27/34),2组比较差异有统计学意义(χ2=5.100,P=0.024)。结论穴位神经电刺激可改善OAB患者尿频、尿急等症状,疗效优于单纯口服酒石酸托特罗定治疗。

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abstractsObjective To study the effect of acupoint electrical nerve stimulation combined with tolterodine on the female patients with overactive bladder (OAB) and air shower type.Methods Seventy patients with OAB (air shower type) were randomly divided into treatment group and control group (35 patients in each group). The patients in both groups were given oral tolterodine, and the treatment group were added with the acupoint electrical nerve stimulation. Overactive bladder symptom score (OABSS), quality of life (QOL) score, urinary diary in both groups before treatment and after 20 days of treatment were assessed. Results After treatment, total effective rate (97.1%vs.79.4%,χ2=5.100) in the treatment group were significantly better than that in the control group (P<0.01). Total score of OABSS (4.54 ± 0.34vs. 6.62 ± 1.43,t=8.251), symptom score of urgency of urination (1.26 ± 0.32vs. 2.78 ± 0.43,t=16.535), score of QOL (1.65 ± 0.35vs. 2.25 ± 0.32, t=7.377), mean frequency of micturition/24 h (7.03 ± 1.21 times/24 hvs. 9.63 ± 1.32 times/24 h,t=8.466), mean frequency of urgency of urination/24 h (0.24 ± 0.12 times/24 hvs. 1.32 ± 0.63 times/24 h,t=9.819), mean frequency of urinary incontinence/72 h (0.38 ± 0.14 times/72 hvs. 1.09 ± 0.36 times/72 h,t=10.718), mean urinary volume (241.38 ± 20.32 mlvs. 184.82 ± 21.43 ml,t=11.167) and mean frequency of nocturia (0.46 ± 0.22 times/nightvs. 1.35 ± 0.36 times/night,t=12.300) in the treatment group were significantly better than those&nbsp;in the control group (P<0.01).Conclusions The treatment of OAB (air shower type) with acupoint electrical nerve stimulation could reduce the symptoms of frequency of micturition and urgency of urination, and promote the treatment effects.

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