摘要目的 评价抗癌消臌方敷脐结合口服螺内酯治疗恶性腹水的疗效.方法 将符合纳入标准的56例恶性腹水患者采用随机数字表法分为2组,每组28例.对照组口服螺内酯,治疗组在对照组基础上加用抗癌消臌方敷脐.2组用药14 d、观察14 d,均于治疗后30 d统计疗效.观察2组腹围、24 h尿量变化,评价腹水疗效、中医证候疗效、生活质量变化.结果 治疗后,治疗组腹水暗区最大深度差值高于对照组(Z=-2.553,P=0.011)、腹围差值低于对照组(Z=-2.264,P=0.024),2组24 h尿量差值比较差异无统计学意义(Z=-1.770,P=0.077).治疗组腹水疗效总有效率为92.9％(26/28)、对照组为89.3％(25/28),2组比较差异无统计学意义(χ2=0.220,P=0.556);治疗组中医证候疗效总有效率为71.4％(20/28)、对照组为35.7％(10/28),2组比较差异有统计学意义(Z=-2.655,P=0.008).结论 抗癌消臌方敷脐结合口服螺内酯可有效减少恶性腹水患者的腹水程度,改善临床症状,提高生活质量,疗效优于单纯口服螺内酯治疗.

abstractsObjective To observe the clinical efficacy of umbilical compress with anti-cancer Xiaogu formula in managing malignant ascites. Methods A total of 56 patients with malignant ascites who met the inclusion criteria were randomized into 28 patients in the treatment group and 28 patients in the control group. The control group was treated with one type of diuretic, and the treatment group was given umbilical compress using Anti-Cancer Xiaogu formula and diuretics. Both groups were treated for 14 days. The changes of abdominal girth, 24 h urine volume, ascites efficacy, TCM syndrome scores, quality of life and adverse reactions were observed. Results The decrease in the maximum depth difference of the ascites in the treatment group was significantly greater than that of the control group (1.16 ± 1.29 vs. 0.00 ± 1.34, Z=-2.553). The difference was statistically significant (P<0.05). The decrease in abdominal girth in the treatment group was significantly larger than that in the control group (0.57 ± 0.55 vs. 2.61 ± 0.28, Z=-2.264). The difference was statistically&nbsp;significant (P<0.05). The in 24-hour urine volume in the treatment group after intervention (-800.18 ± 64.12 vs.-683.57 ± 55.38, Z=-1.770) was no statistically significant (P>0.05). The response rate in the treatment group was 92.9％ (26/28), while that of the control group was 89.3％ (25/28).treatment group was 71.4％, while that of the control group was 35.7％. The difference was statistically significant (P<0.05). The increase in KPS in the treatment group was significantly higher than that of the control group. The difference was statistically significant (P<0.05). Conclusions Anti-cancer Xiaogu umbilical cord combined with diuretic can reduce the degree of malignant ascites, alleviate clinical symptoms, improve quality of life and decrease the occurrence of adverse reactions when used concomitantly with diuretics in the management of malignant ascites.