摘要目的 探讨加味逍遥散对肝郁脾虚型非糜烂性反流病(non-erosive reflux disease,NERD)患者促生长素、血管活性肠肽(vasoaetive intestinal peptide,VIP)水平的影响.方法 将符合入选标准的70例肝郁脾虚型NERD患者按随机数字表法分为2组,每组35例.治疗组口服加味逍遥散免煎颗粒,对照组口服奥美拉唑肠溶片与多潘立酮片.2组均治疗8周.采用ELISA法检测血浆促生长素、VIP含量.结果 治疗后,治疗组血浆促生长素水平[(210.96±16.85) pg/ml比(195.75±12.62) pg/ml,t=4.274]高于对照组(P＜0.01),血浆VIP水平[(16.12±1.41) pg/ml比(18.57±2.68) pg/ml,t=4.786]低于对照组(P＜0.01).结论 加味逍遥散可降低NERD患者血浆VIP水平,升高血浆促生长素水平,有效减缓NERD病程.

abstractsObjective To investigate the effect of Jiawei-Xiaoyao powder on the levels of somatotropin and vasoaetive intestinal peptide (VIP) in patients with non-erosive reflux disease (NERD).Methods Seventy patients with liver-stagnation and spleen-deficiency NERD who met the inclusion criteria were divided into two groups according to the random number table,35 in each group.The treatment group was orally administered with Jiawei-Xiaoyao powder,and the control group was given oral omeprazole enteric-coated tablets and domperidone.Both groups were treated for 8 weeks.Plasma somatotropin and VIP levels were measured by ELISA.Results After treatment,plasma somatotropin levels (210.96 ± 16.85 pg/ml vs.195.75 ± 12.62 pg/ml,t=4.274) in the treatment group were significantly higher than that in the control group (P＜0.01),and plasma VIP level (16.12 ± 1.41 pg/ml vs.18.57 ± 2.68 pg/ml,t=4.786) in the treatment group was significantly lower than that in the control group (P＜0.01).Conclusions The Jiawei-Xiaoyao powder could reduce plasma VIP level in NERD patients,increase plasma somatotropin levels of NERD.