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Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity

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摘要INTRODUCTIONPhysical activity has beneficial consequences on nearly every organ system. In addition to the positive effects of exercise on cardiovascular1 and musculoskeletal health,2 regular physical activity is associated with a reduced risk of colon, endometrial, and breast cancers.3–4 Women who exercise, at a moderate intensity for 3–4 h per week, have a 30％–40％ reduced risk of breast cancer, compared to sedentary women.5 In addition, physical activity is associated with decreased cancer mortality6 and reduced tumor size in mice that ran long distances.

作者 Xin Yi ^[1] Laura E.Wright ^[2] Gabriel M.Pagnotti ^[2] Gunes Uzer ^[3] Katherine M.Powell ^[4] Joseph M.Wallace ^[5] Uma Sankar ^[6] Clinton T.Rubin ^[7] Khalid Mohammad ^[2] Theresa A.Guise ^[2] William R.Thompson ^[8] 学术成果认领

作者单位 Department of Physical Therapy,School of Health and Rehabilitation Sciences,Indiana University,Indianapolis,IN 46202,USA ^[1] Department of Medicine,Division of Endocrinology,School of Medicine,Indiana University,Indianapolis,IN 46202,USA ^[2] Department of Mechanical and Biomedical Engineering,Boise State University,Boise,ID 83725,USA ^[3] Department of Biomedical Engineering,Purdue School of Engineering and Technology,Purdue University,Indianapolis,IN 46202,USA ^[4] Department of Biomedical Engineering,Purdue School of Engineering and Technology,Purdue University,Indianapolis,IN 46202,USA;Department of Anatomy&Cell Biology,Indiana University,Indianapolis,IN 46202,USA ^[5] Department of Anatomy&Cell Biology,Indiana University,Indianapolis,IN 46202,USA ^[6] Department of Biomedical Engineering,Stony Brook University,Stony Brook,NY 11794,USA ^[7] Department of Physical Therapy,School of Health and Rehabilitation Sciences,Indiana University,Indianapolis,IN 46202,USA;Department of Anatomy&Cell Biology,Indiana University,Indianapolis,IN 46202,USA ^[8]

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发布时间 2021-03-16（万方平台首次上网日期，不代表论文的发表时间）

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