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A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone

摘要INTRODUCTIONTransforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) play important roles in bone metabolism.1–3 Genetic mutations in TGF-βor BMP signaling pathway components cause heritable developmental bone diseases, and dysregulation of TGF-β or BMP signaling is often associated with osteoporosis or osteoarthritis.

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作者 Junichi Kushioka [1] Takashi Kaito [1] Rintaro Okada [1] Hiroyuki Ishiguro [1] Zeynep Bal [1] Joe Kodama [1] Ryota Chijimatsu [2] Melanie Pye [3] Masahiro Narimatsu [3] Jeffrey L.Wrana [3] Yasumichi Inoue [4] Hiroko Ninomiya [5] Shin Yamamoto [6] Takashi Saitou [7] Hideki Yoshikawa [1] Takeshi Imamura [7] 学术成果认领
作者单位 Department of Orthopaedic Surgery,Osaka University Graduate School of Medicine,2-2 Yamadaoka,Suita,Osaka 565-0871,Japan [1] Bone and Cartilage Regenerative Medicine,The University of Tokyo,7-3-1,Hongo,Bunkyo-ku,Tokyo 113-8655,Japan [2] Centre for Systems Biology,Lunenfeld-Tanenbaum Research Institute,Mount Sinai Hospital,600 University Ave,Toronto,ON M5G 1X5,Canada [3] Department of Cell Signaling,Graduate School of Pharmaceutical Sciences,Nagoya City University,3-1 Tanabe-dori,Mizuho-ku,Nagoya,Aichi 467-8603,Japan [4] Department of Molecular Medicine for Pathogenesis,Ehime University Graduate School of Medicine,454 Shitsukawa,Toon,Ehime 791-0295,Japan [5] Department of Gastroenterology and Metabology,Ehime University Graduate School of Medicine,454 Shitsukawa,Toon,Ehime 791-0295,Japan [6] Department of Molecular Medicine for Pathogenesis,Ehime University Graduate School of Medicine,454 Shitsukawa,Toon,Ehime 791-0295,Japan;Translational Research Center,Ehime University Hospital,454 Shitsukawa,Toon,Ehime 791-0295,Japan [7]
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发布时间 2021-03-16(万方平台首次上网日期,不代表论文的发表时间)
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骨研究(英文版)

骨研究(英文版)

2020年8卷4期

429-438页

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