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MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS

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摘要INTRODUCTIONOsteoclasts are myeloid lineage cells that resorb bone.1–2 As bone constantly remodels, remodeling is tightly regulated by osteo-clasts, bone-forming osteoblasts, and osteocytes.3 The balance between bone resorption and formation is critically important for the maintenance of skeletal integrity and disruption of this balance results in pathological changes in bone structure and quality. Overly active osteoclasts lead to an imbalance, tipping the scale toward more bone resorption than formation and leading to pathological bone loss, such as occurs in patients with osteo-porosis.

作者 Takayuki Fujii ^[1] Koichi Murata ^[2] Se-Hwan Mun ^[1] Seyeon Bae ^[1] Ye Ji Lee ^[1] Tannia Pannellini ^[1] Kyuho Kang ^[3] David Oliver ^[1] Kyung-Hyun Park-Min ^[4] Lionel B.Ivashkiv ^[5] 学术成果认领

作者单位 Arthritis and Tissue Degeneration Program and David Z.Rosensweig Genomics Research Center,Hospital for Special Surgery,New York,NY 10021,USA ^[1] Arthritis and Tissue Degeneration Program and David Z.Rosensweig Genomics Research Center,Hospital for Special Surgery,New York,NY 10021,USA;Department of Orthopaedic Surgery,Kyoto University Graduate School of Medicine,Sakyo,Kyoto 606-8507,Japan;Department of Advanced Medicine for Rheumatic Diseases,Kyoto University Graduate School of Medicine,Sakyo,Kyoto 606-8507,Japan ^[2] Arthritis and Tissue Degeneration Program and David Z.Rosensweig Genomics Research Center,Hospital for Special Surgery,New York,NY 10021,USA;Department of Biology,Chungbuk National University,Cheongju 28644,Republic of Korea ^[3] Arthritis and Tissue Degeneration Program and David Z.Rosensweig Genomics Research Center,Hospital for Special Surgery,New York,NY 10021,USA;BCMB Allied Program,Weill Cornell Graduate School of Medical Science,New York,NY 10021,USA ^[4] Arthritis and Tissue Degeneration Program and David Z.Rosensweig Genomics Research Center,Hospital for Special Surgery,New York,NY 10021,USA;Immunology and Microbial Pathogenesis Program,Weill Cornell Graduate School of Medical Science,New York,NY 10021,USA ^[5]

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ORIGINAL ARTICLES

发布时间 2021-05-17（万方平台首次上网日期，不代表论文的发表时间）

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