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3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease

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摘要INTRODUCTIONBack pain is a global healthcare concern and economic burden. It is the leading cause of years lived with disability, with estimates that over 80％of adults will suffer from symptoms at some time in their lives1. Intervertebral disc degeneration (IVDD) is one of the major causes of back pain symptoms, one of the first pathological signs, and a potential target for intervention2. As the global population ages, a substantial increase in morbidity due to degenerative diseases and back pain is expected;3 this increase emphasizes the importance of improving our understanding of the causes of IVDD and its relationship with other common degenerative conditions to revise or further develop novel therapeutic strategies.

作者 Erika Kague ^[1] Francesco Turci ^[2] Elis Newman ^[1] Yushi Yang ^[3] Kate Robson Brown ^[4] Mona S.Aglan ^[5] Ghada A.Otaify ^[5] Samia A.Temtamy ^[5] Victor L.Ruiz-Perez ^[6] Stephen Cross ^[7] C.Patrick Royall ^[8] P.Eckhard Witten ^[9] Chrissy L.Hammond ^[1] 学术成果认领

作者单位 School of Physiology,Pharmacology and Neuroscience,Biomedical Sciences,University of Bristol,Bristol,UK ^[1] School of Physics,HH Wills Physics Laboratory,University of Bristol,Bristol,UK ^[2] School of Physics,HH Wills Physics Laboratory,University of Bristol,Bristol,UK;Centre for Nanoscience and Quantum Information,University of Bristol,Bristol,UK;Bristol Centre for Functional Nanomaterials,University of Bristol,Bristol,UK ^[3] Department of Anthropology and Archaeology,University of Bristol,Bristol,UK;Department of Mechanical Engineering,University of Bristol,Bristol,UK ^[4] Clinical Genetics Department,Human Genetics and Genome Research Division,Center of Excellence for Human Genetics,National Research Centre,Cairo,Egypt ^[5] Instituto de Investigaciones,Biomedicas de Madrid,and Ciber de Enfermedades Raras(CIBERER),Madrid,Spain ^[6] Wolfson Bioimaging Facility,Biomedical Sciences,University of Bristol,Bristol,UK ^[7] School of Physics,HH Wills Physics Laboratory,University of Bristol,Bristol,UK;School of Chemistry,University of Bristol,Bristol,UK ^[8] Evolutionary Developmental Biology,Department of Biology,Ghent University,Ghent,Belgium ^[9]

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ORIGINAL ARTICLES

发布时间 2022-02-25（万方平台首次上网日期，不代表论文的发表时间）

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