An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+mononuclear cells and PDGF-BB secretion

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摘要INTRODUCTIONSiglec-15 is a member of the sialic acid-binding immunoglobulintype lectin (Siglecs) family, a group of cell-surface receptors that potentially regulate the adaptive immune response via cell–cell interactions with target cells through their sialic acid-binding Nterminal Ig-like V-type domain. Unlike most other Siglec family members, Siglec-15 has been conserved throughout vertebrate evolution and is expressed primarily by macrophages and dendritic cells.1 Previous studies have shown that the expression of Siglec-15 is upregulated in mature osteoclasts.

作者 Gehua Zhen ^[1] Yang Dan ^[2] Ruomei Wang ^[1] Ce Dou ^[1] Qiaoyue Guo ^[1] Melissa Zarr ^[3] Linda N.Liu ^[3] Lieping Chen ^[4] Ruoxian Deng ^[5] Yusheng Li ^[1] Zengwu Shao ^[6] Xu Cao ^[5] 学术成果认领

作者单位 Department of Orthopedic Surgery,Institute of Cell Engineering,Johns Hopkins University School of Medicine,Baltimore,MD,USA ^[1] Department of Orthopedic Surgery,Institute of Cell Engineering,Johns Hopkins University School of Medicine,Baltimore,MD,USA;Department of Orthopedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China ^[2] NextCure,Inc.,Beltsville,MD,USA ^[3] Department of Immunobiology,Yale University School of Medicine,New Haven,CT,USA ^[4] Department of Orthopedic Surgery,Institute of Cell Engineering,Johns Hopkins University School of Medicine,Baltimore,MD,USA;Department of Biomedical Engineering,Johns Hopkins University School of Medicine,Baltimore,MD,USA ^[5] Department of Orthopedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China ^[6]

栏目名称 ORIGINAL ARTICLES

发布时间 2022-02-25

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