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The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development

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摘要INTRODUCTIONIn addition to its structural function, the collagen-rich extra-cellular matrix (ECM) of bone has important role in establishing and maintaining cellular organization through control of proliferation, migration, differentiation, and remodeling.1–3 These ECM functions are controlled by receptor-mediated interactions with progenitor cells. Disruption of cell-ECM interactions has been implicated in a wide spectrum of human skeletal disorders, including skeletal dysplasias, chondrodyspla-sias, osteoarthritis, and osteoporosis.1,4–6 Specific interactions between collagens and skeletal progenitors are mediated by cell-surface receptors, principally β1 integrins and discoidin domain receptors (DDRs).

作者 Fatma F.Mohamed ^[1] Chunxi Ge ^[1] Randy T.Cowling ^[2] Daniel Lucas ^[3] Shawn A.Hallett ^[1] Noriaki Ono ^[4] Abdul-Aziz Binrayes ^[5] Barry Greenberg ^[2] Renny T.Franceschi ^[6] 学术成果认领

作者单位 Department of Periodontics&Oral Medicine,University of Michigan,Ann Arbor,MI,USA ^[1] Division of Cardiovascular Medicine,University of California at San Diego,San Diego,CA,USA ^[2] Division of Experimental Hematology and Cancer Biology,Cincinnati Children's Medical Center,Cincinnati,OH,USA;Department of Pediatrics,Cincinnati Children's Hospital,Cincinnati,OH,USA ^[3] Department of Orthodontics&Pediatric Dentistry,University of Michigan,Ann Arbor,MI,USA ^[4] Department of Prosthetic Dental Sciences,College of Dentistry,King Saud University,Riyadh,Saudi Arabia ^[5] Department of Periodontics&Oral Medicine,University of Michigan,Ann Arbor,MI,USA;Department of Biological Chemistry,School of Medicine,University of Michigan,Ann Arbor,MI,USA;Department of Biomedical Engineering,University of Michigan,Ann Arbor,MI,USA ^[6]

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ORIGINAL ARTICLES

发布时间 2022-04-07（万方平台首次上网日期，不代表论文的发表时间）

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