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Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression

摘要INTRODUCTIONOsteoarthritis (OA) is one of the most common orthopedic diseases worldwide,1–2 with an approximately 26.6% prevalence rate among people over 45 years old.3 The most prominent pathological changes of OA include articular cartilage degeneration, osteophyte formation, low-grade inflammation and subchondral bone remodeling.4–8 After initial mechanical erosion during aging, articular cartilage and synovium express a panel of proteolytic enzymes and proinflammatory factors that accelerate cartilage matrix degradation and OA progression.9–11 Early-stage OA patients can be treated by microfracture, osteochondral allograft transplantation, or biomaterial implantation,12–13 while late-stage OA patients can only be treated by replacement plastic surgeries.14 Pharmacological treatments such as nonsteroidal antiinflammatory drugs and intra-articular glucocorticoid injection are recommended by most guidelines to relieve inflammation and pain.15–17 In contrast, the effectiveness of other drugs, such as glucosamine, chondroitin and hyaluronic acid, remains controversial.15–17 Therefore, drugs with higher efficacy for OA treatment are under intensive investigation.

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作者 Aoyuan Fan [1] Genbin Wu [2] Jianfang Wang [3] Laiya Lu [1] Jingyi Wang [1] Hanjing Wei [3] Yuxi Sun [4] Yanhua Xu [5] Chunyang Mo [3] Xiaoying Zhang [3] Zhiying Pang [1] Zhangyi Pan [1] Yiming Wang [1] Liangyu Lu [1] Guojian Fu [2] Mengqiu Ma [4] Qiaoling Zhu [3] Dandan Cao [3] Jiachen Qin [3] Feng Yin [6] Rui Yue [7] 学术成果认领
作者单位 Department of Joint Surgery,Shanghai East Hospital,Tongji University School of Medicine,Shanghai 200092,China [1] Department of Orthopedic Surgery,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200240,China [2] Institute for Regenerative Medicine,Shanghai East Hospital,Frontier Science Center for Stem Cell Research,Shanghai Key Laboratory of Signaling and Disease Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China [3] Department of Cardiology,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China [4] Institute for Regenerative Medicine,Shanghai East Hospital,Frontier Science Center for Stem Cell Research,Shanghai Key Laboratory of Signaling and Disease Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China;Department of Cardiology,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China [5] Department of Joint Surgery,Shanghai East Hospital,Tongji University School of Medicine,Shanghai 200092,China;Shanghai Institute of Stem Cell Research and Clinical Translation,Shanghai 200120,China;Shanghai Clinical Research Center for Aging and Medicine,Shanghai 200040,China [6] Institute for Regenerative Medicine,Shanghai East Hospital,Frontier Science Center for Stem Cell Research,Shanghai Key Laboratory of Signaling and Disease Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China;Shanghai Institute of Stem Cell Research and Clinical Translation,Shanghai 200120,China [7]
栏目名称 ORIGINAL ARTICLES
发布时间 2023-04-17
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骨研究(英文版)

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2023年11卷1期

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