O-glycosylation in liver cancer:Clinical associations and potential mechanisms

二维码有效期 120s

摘要Liver cancer can be an aggressive disease,and is highly prevalent in Asia and Africa.However,its currently approved therapeutic strategies are far from satisfactory.Recent progress in genomic,prote-omic and glycomic profiling technologies have enabled the identification of biomarkers that significantly correlate with clinical outcomes.Many biomarkers are related to O-glycosylation of glycoproteins,which belong to an important but less-explored field of liver cancer biology.Here,we review these clinical studies and discuss potential underlying mechanisms.

作者 Kung-Hao Liang ^[1] Chau-Ting Yeh ^[2] 学术成果认领

作者单位 Liver Research Center,Chang Gung Memorial Hospital,Taoyuan,Taipei,China;Medical Research Department,Taipei Veterans General Hospital,Taipei,China ^[1] Liver Research Center,Chang Gung Memorial Hospital,Taoyuan,Taipei,China;Molecular Medicine Research Center,Chang Gung University,Taoyuan,Taipei,China ^[2]

关键词 O-glycosylation Post-translational modification Glycobiology Biomarkers Hepatocellular carcinoma(HCC)Glycosyltransferase

栏目名称 Review Articles

DOI 10.1016/j.livres.2017.12.005

发布时间 2024-05-06

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交