B lymphocyte-mediated humoral immunity in the pathogenesis of chronic hepatitis B infection

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摘要During hepatitis B virus(HBV)infection,the host immune response,including the presence of functional HBV-specific T cells and HBV-specific antibody-producing B cells,ultimately determines the HBV infection outcome:either the virus is cleared,or infection persists.Functional exhaustion of HBV-specific CD8+cytotoxic T cells is the most important immune feature in chronic HBV infection.However,chronic HBV infection also re-writes humoral immunity,whereby B cells are the leading participants.In this review,we highlight HBV-specific B cell responses and propose future directions for research aimed at the generation of more efficient immunotherapeutic strategies.

作者 Jing Pan ^[1] Tiantian Yao ^[1] Hao Cheng ^[1] Yan Zhu ^[2] Yan Wang ^[1] 学术成果认领

作者单位 Department of Infectious Diseases,Peking University First Hospital,Beijing,China ^[1] Department of Oncology,Peking University First Hospital,Beijing,China ^[2]

关键词 Hepatitis B virus(HBV)Humoral immunity HBV-specific B cell Atypical memory B cell Cytokines

栏目名称

Review Articles

DOI 10.1016/j.livres.2020.07.001

发布时间 2024-05-06

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