摘要The 4th Chinese American Liver Society(CALS)/Society of Chinese Bioscientists in America(SCBA)Hepatology Division Annual Symposium was held virtually on October 29-30,2021.The goal of the CALS Symposium was to present and discuss the recent research data on the pathogenesis and therapeutic targets of liver diseases among the CALS members,trainees and invited speakers.Here we briefly introduce the history of the CALS/SCBA Hepatology Division and highlight the presentations that focus on the current progresses on basic and translational research in liver metabolism,bile acid biology,alcohol-related liver disease,drug-induced liver injury,cholestatic liver injury,non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and liver cancer.