摘要Objective: To assess the fruit of Feijoa sellowiana Berg var. coolidge and gorgiona, cultured in Sicily, for its gastroprotective effect, in association with performing phytochemical evaluation.Methods:The gastroprotective effect was investigated on ethanol-induced ulcers in rats, with sucralfate as reference drug. Samples of gastric mucosae, stained by periodic acid-Shiff and haematoxylin/eosin, were observed by light microscopy.Results:By means of HPLC, vitamin E complex and polyphenol compounds were determined. identified, while δ was only in var. coolidge. In whole fruit of two varieties, catechin, eriodictyol, eriocitrin, pyrocatechol, quercetin, rutin, ellagic, gallic and syringic acid were determined. The fruit showed gastroprotective effect (ulcer index: var. coolidge=1.07, var. gorgiona=1.02). The efficacy was comparable to that of sucralfate (ulcer index 1.10). Histological examination confirmed the inhibition of ulcerogenic activity of the ethanol.Conclusions:In pulp and peel samples of both varieties of fruit α, β and γ tocopherols were and show beneficial effects on various diseases, particularly those caused by oxidative processes resulting in cell damage. The amount of polyphenols and vitamin E complex confirms the nutritional value of this fruit, grown in pedoclimatic condition very different from the origin area. Active principles of Feijoa sellowiana can play an important role in human diet and show beneficial effects on various diseases, particularly those caused by oxidative processes resulting in cell damage. The amount of polyphenols and vitamin E complex confirms the nutritional value of this fruit, grown in pedoclimatic condition very different from the origin area.