摘要Objective: To explore the antibacterial activity of Elaeocarpus floribundus fruits aqueous extracts against methicillin resistant Staphylococcus aureus (MRSA) clinical isolates. Methods: The fresh olive fruits were collected, dried and milled in order to prepare aqueous extracts of olive seed and olive mesocarp-epicarp. The extracts were tested against clinical isolates of MRSA by agar well diffusion method, and the diameter of inhibition zone was recorded, and antibacterial capacity of the extracts (AU/mL) was determined. Results: The MRSA isolates were sensitive to aqueous extract of olive mesocarp-epicarp with diameter of inhibition zone ranging from (11.670 ± 0.577) to (15.330 ± 0.577) mm; the olive aqueous seed extract had no anti-MRSA activity. The antibacterial capacity of the extracts against the tested MRSA isolates ranged from 733.33 to 800 AU/mL. Conclusions: The olive fruits can be used as a new source of plant based non-antibiotic biotherapeutic agents for the treatment of MRSA infection.