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Hepatobiliary surgeons meet immunologists: the case of colorectal liver metastases patients

摘要The burgeoning field of cancer immunology demands a change in the paradigm of cancer patient management. The understanding of the course of a given malignant disease should also include the host immune system as one of the key factors in determining the patient's prognosis. Surgical and medical oncologists need to understand the basic and advanced applications of immunotherapies, which are rapidly evolving, and are nowadays an integral part of the armamentarium for the treatment of cancer patients. In the present work, we review the current knowledge concerning the immune landscape of colorectal cancer (CRC) patients with liver metastases, as recently discovered.

作者单位 Department of Hepatobiliary and General Surgery, Humanitas University, Pieve Emanuele, Italy;Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy ^[1] Department of Immunology and Inflammation, Humanitas Clinical and Research Center, Rozzano, Milan, Italy ^[2] Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy;Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy ^[3] Department of Hepatobiliary and General Surgery, Humanitas University, Pieve Emanuele, Italy ^[4] Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy;Department of Immunology and Inflammation, Humanitas Clinical and Research Center, Rozzano, Milan, Italy;The William Harvey Research Institute, Queen Mary University of London, London, UK ^[5]

关键词 Host immune system colorectal liver metastases (CLM)colorectal cancer liver metastases colorectal cancer (CRC)immune response immunotherapy

栏目名称

Review Article

DOI 10.21037/hbsn.2019.03.06

发布时间 2019-08-29（万方平台首次上网日期，不代表论文的发表时间）