Comparable investigation in dopamine transporters with 99mTc-TRODAT-1 and 131I-FP-CIT SPECT in Parkinson's disease patients

二维码有效期 120s

摘要Dopamine transporter (DAT) mediates the regulation of dopaminergic function. Two agents of TRODAT-1and FP-CIT were observed in evaluating DAT change of Parkinson's disease (PD). The relationship between them was also evaluated. The results suggested that 99mTc-TRODAT-1 SPECT and 131I-FP-CIT SPECT may serve as sensitiveand objective in vivo markers to reflect the severity of PD. The 99mTc-TRODAT-1 image is more accurate and clearercompared with 131I-FP-CIT.

作者单位 Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China ^[1] Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China ^[2]

关键词 99mTc-TRODAT-1 SPECT 131I-FP-CIT SPECT Parkinson's disease

分类号 R445 R445.6

栏目名称 RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

发布时间 2008-03-05

基金项目

NationalScientific Technique Research Plan Project

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