摘要Objective:This study aimed to develop and apply a closed-loop medication administration system in a hospital in order to reduce medication administration errors (MAEs).Methods:The study was implemented in four pilot general wards.We used a before-and-after design to collect oral medication administration times before and after the implementation of the closed-loop medication administration system,evaluated MAE alert logs after the intervention,and conducted a survey of the nurses' satisfaction with the system in the pilot wards.Results:(a) Nursing time of oral medication administration:before the adoption of the closed-loop medication administration system,the average nursing time was 31.56 ± 10.88 minutes (n =78);after the adoption of the system,the time was 18.74 ± 5.60 minutes (n =54).Independent sample t-tests showed a significant difference between two groups (t =8.85,P＜0.00).(b) Degree of nurses' satisfaction with the closed-loop medication administration system:60.00％ (n =42) of nurses considered the system to be helpful for their work and nearly half of the nurses (47.14％,n =33) believed that the system could facilitate clinical work and reduce workload;51.43％ (n =36) believed that the system could reduce checking time and enhance work efficiency;82.86％ (n =58) believed that the system was helpful in improving checking accuracy to reduce MAEs and ensure patient safety.More than 60％ of the nurses considered the system to be a method that could help to track MAEs to improve nursing quality.(c) The MAE alert logs during observation period:it revealed only 27 alerts from the repeated scans of 3,428 instances of medication administration.Conclusions:The nurses were satisfied with the closed-loop medication administration system because it improved their work efficiency and reduced their workload.The current investigation was limited by time;therefore,further research is needed to more closely examine the relationship between the system and MAEs.