摘要Objective: The objective of this study was to evaluate the effect of empowerment education on depression level and laboratory indicators of patients treated with hemodialysis. Methods: We searched databases including Cochrane Library, Web of Science, Embase, PubMed, Chinese Biomedical Literature Database (CBM), Chinese Academic Journals Full-text Database (CNKI), VIP, and Wanfang. We included all the researches about the application of empowerment education in patients treated with hemodialysis. We used RevMan 5.3 to analyze the data after assessing the quality of researches. Results: We included 10 studies eventually. The results of meta-analysis showed that the self-efficacy [MD = 1.10, 95％ confidence interval (CI; 0.71, 1.48), P < 0.01], depression [MD = -6.94, 95％ CI (-8.53, -5.34), P < 0.01], serum creatinine [Scr; MD = -116.46, 95％ CI (-171.90, -61.03), P < 0.01], albumin [Alb; MD = 2.93, 95％ CI (2.00, 3.86), P < 0.01], and blood urea nitrogen [BUN; MD = -0.95, 95％ CI (-1.89, -0.01), P = 0.05] in the empowerment education group had significantly statistical difference compared with those in the usual education group. However, there was no significant difference in hemoglobin [Hb; MD = 3.03, 95％ CI (-0.64, 6.70), P = 0.11] between two groups. Conclusions: Empowerment education can improve the self-efficacy in patients treated with hemodialysis, relieve depression, and improve Scr, Alb, and BUN. However, there is no significant improvement in Hb; it needs further exploration in clinical practice.