摘要Objective:This study aimed to determine the relationships between e-learning quality,student satisfaction,and learning outcomes and the mediating effect of student satisfaction.Methods:A cross-sectional quantitative correlational study using a predictive design and multivariate analysis method was employed in this study.A sample of 241 nursing students were recruited through an online survey based on a stratified random sampling technique.The variance-based Partial Least Squares Structural Modeling analysis method was used to test the possible relationship and mediating effect among the variables.Results:The findings revealed statistically significant relationships between e-learning quality,student satisfaction,and learning outcomes.A mediating effect of 37.2％is predicted for e-learning quality on learning outcomes through student satisfaction.Conclusions:This study emphasizes the learning needs of working nurses and the impact on their learning outcomes in e-learning nursing undergraduate programs.Advances in e-learning education have assisted nurses to be more self-sufficient in their pursuit of lifelong learning.