摘要Objective:To explore the association of sensory processing sensitivity(SPS)and stigma as well as the mediating role of fear of progression(FoP)in lung cancer patients.Methods:Two hundred and forty-two lung cancer patients completed a self-reported questionnaire,which included the highly sensitive person scale(HSPS),fear of progression questionnaire-short form(FoP-Q-SF),and the Cataldo Lung Cancer Stigma Scale(CLCSS).Results:CLCSS was positively correlated with FoP(Pearson correlation=0.217,P＜0.01)and HSPS(Pearson correlation=0.187,P＜0.01),FoP was positively correlated with HSPS(Pearson correlation=0.199,P＜0.01).FoP played a mediating role between SPS and stigma(a × b=0.025,95％confidence intervals[Cl][0.004,0.054]),and the proportion of mediating effect(ab/c)was 21％(ab=0.025,c=0.120).Conclusions:Patients with higher SPS reported higher level of stigma,and FoP has a mediating role between SPS and stigma.Our discussion deemed that psychological intervention may help higher SPS patients reduce the harm of FoP and further reduce stigma.