摘要Objective:To explore the effect of the changes of IL-2 and IL-6 levels in liver injury patients on the immune response of hepatitis B vaccine and its mechanism.Methods:A total of 32 liver injury patients who were admitted in our hospital from June, 2013 to October, 2014 were included in our study and served as the liver injury group; while 20 healthy individuals who came for physical examination at the same period were served as the control group. The chemiluminescence was used to measure the titers of HBsA antibody in the two groups; FCM was utilized for detecting the lymphocyte subsets in the blood; and the content of serum IL-2 and IL-6 levels was determined by ELISA. Results:The anti HBsAb monoclonal antibody titers in the liver injury group were significantly lower than those in the control group (P<0.05). The contents of CD3+, CD4+, CD19+ and NK cells in the liver injury group were significantly lower than those in the control group, the content of CD8+ cell was significantly higher than that in the control group, and the ratio of CD4/CD8 was significantly lower than that in the control group (P<0.05). The content of serum IL-2 in the liver injury group was significantly lower than that in the control group, while IL-6 was significantly higher than that in the control group (P<0.05).Conclusions: Liver injury can cause the change of IL-2 and IL-6 levels in the body to reduce the effect of the immune response of hepatitis B vaccine, resulting in an immune system disorder.