摘要Objective:To explore the correlation between MFG-E8 and CHD in elderly patients with MIRI, and to provide help for CHD patients with ischemic reperfusion therapy in the future. Methods:A total of 94 CHD patients in our hospital were selected as the observation group and treated with reperfusion operation. The patients with chest discomfort and no significant stenosis of coronary artery were selected as control group; Before and after operation, the changes of MFG-E8 and the downstream factor MCP-1, TGF-β1, inflammatory factors hs-CRP, IL-6 and ICAM-1 in each group were detected in 24 h and 48 h after operation, and the correlation between MFG-E8 with various indexes and MIRI was analyzed.Results:MFG-E8 at each time point of the observation group were significantly lower than that of the control group (P<0.05), and were significantly increased as comparison of the preoperative (P<0.05). The level of MFG-E8 in postoperative 48 h was higher than 24 h; in the control group, the change of MFG-E8 and inflammatory factors hs-CRP, IL-6, ICAM-1 at different time points was not significant (P>0.05); the level of inflammatory factors hs-CRP, IL-6, ICAM-1 at each time points of the observation group were significantly higher than that of the control group (P<0.05); the levels of inflammatory factors were significantly higher than those preoperative (P<0.05), the level of hs-CRP at 48 h was significantly lower than that at 24 h, IL-6 and ICAM-1 were increased over time; the level of inflammatory factors were negatively correlated with MFG-E8. In the observation group, the serum TNF-β, MCP-1 and at different time points were significantly higher than those in the control group (P<0.05); TNF-β and MCP-1 were significantly higher than that before operation, and the TNF-β and MCP-1 in 48 h were significantly higher than those in 24 h (P<0.05); TNF-β and MCP-1 were positively correlated with MFG-E8.Conclusions:Inflammation plays a key role in elderly patients with MIRI. MFG-E8 acts as a defense against inflammation, and can help in reducing MIRI, which provids help for the future treatment of myocardial ischemia reperfusion.