摘要Objective:To analyze the effect of different anesthesia induction on adrenal cortex and medulla activation levels as well as immune cell levels in patients after radical operation of tongue cancer.Methods:A total of 45 patients with tongue cancer received radical operation of tongue cancer, 24 cases of observation group received total intravenous induction and maintenance, 21 cases of control group accepted combined intravenous-inhalation induction and maintenance, and then differences in adrenal cortex and medulla activation levels as well as immune cell levels 1h after operation were compared between two groups.Results:Serum GC and ALDO as well as urine 17-OH and 17-KS levels of observation group 1h after treatment were lower than those of control group (P<0.05); serum ADM, E and NE as well as urine VMA levels were lower than those of control group (P<0.05); peripheral blood CD3-CD16+56+ and CD3-CD19+ cell levels, CD3+ and CD4+T lymphocyte levels and CD4+/ CD8+ratio were higher than those of control group (P<0.05).Conclusions:Application of sevoflurane in surgical anesthesia may be the main cause of postoperative stress and immune injury in patients with tongue cancer.