摘要Objective: To verify the efficacy of the Chinese medicine "Zhiyang Pingfu Liquid" on the lesion associated with Epidermal Growth Factor Receptor Inhibitors (EGFRIs). Methods: Female BN rats were divided into Control group and Gefitinib group randomly. The Gefitinib group was administered gefitinib for 21 days. After 21 days, the rats in the Gefitinib group were grouped again and randomly divided into Model group, Gefitinib + ZY group, and Gefitinib + NS group. Starting from day 22, rats in Gefitinib+ZY or NS were given different drugs for 7 days besides the other conditions are as the same as before. Observe the morphological changes and histopathological changes of the skin during the research. The changes of inflammatory factors such as TNF-α and IL-6 in the serum of were detected by ELISA. Results: The application of "Zhiyang Pingfu Liquid" for 7 days could significantly reduce the skin inflammation whether in gross or pathological view. The concentration of TNF-α and IL-6 in Gefitinib+ZY is significantly lower than those in the Model group (P=0.002, P=0.002) and there is no significant changes compared with the Control group (P=0.279, P=0.165). Conclusion: Chinese herbal "Zhiyang Pingfu Liquid" can reduce the lesion and inflammatory caused by EGFRIs.