摘要Objective: To observe the clinical effect of kidney-tonifying and colllateral-tonifying acupuncture combined with thermosensitive moxibustion in the treatment of knee osteoarthritis and cold congealing syndrome and the effect on Tartrate-resistant Acid Phosphatase (TRACP) and Ⅰ collagen C-terminal foreign body peptide (CTX-I). Methods:Totally 90 patients with knee osteoarthritis were divided into three groups: acupuncture group, thermosensitive moxibustion group and routine group with 30 cases in each group. In the conventional group, sodium hyaluronate was injected into the joint cavity and diclofenac sustained release tablets were taken orally. Thermosensitive moxibustion group was given thermosensitive moxibustion on the basis of conventional treatment. Acupuncture and moxibustion group in the heat sensitive moxibustion group treatment was given kidney tonifying acupuncture. VAS score, JKOM score and Ly-Sholm knee score were observed before and after treatment and followed up for 2 weeks. The levels of TRACP and CTX-I in serum before and after treatment. Results: Before treatment, there were statistically significant differences in VAS score, JKOM score and Ly-Sholm knee score among all groups (P>0.05). After treatment, the VAS score and JKOM score decreased, and the decrease degree was the greatest in the acupuncture group (P<0.05). Ly-Sholm knee score increased, and the change degree was the greatest in acupuncture group (P<0.05). Before treatment, the levels of TRACP and CTX-I in serum of all groups were significantly different (P>0.05). After treatment, serum TRACP and CTX-I levels were decreased, and the decrease degree was the greatest in acupuncture group (P<0.05). The total effective rates of the acupuncture group, the thermal sensitive moxibustion group and the conventional group were 96.7％, 80％ and 66.7％, respectively, and the difference between each group was statistically significant (P<0.05). Conclusion: Kidney-tonifying and collature-tonifying acupuncture combined with thermosensitive moxibustion can significantly relieve knee pain and other symptoms of knee osteoarthritis in patients and cold congealing syndrome, which is worthy of clinical promotion.