首页 > 国际结核病与肺部疾病杂志（中文版） > 左氧氟沙星、加替沙星及莫西沙星对肺结核患者的早期及延长早期杀菌活性

左氧氟沙星、加替沙星及莫西沙星对肺结核患者的早期及延长早期杀菌活性

Early and extended early bactericidal activity of levofloxacin,gatifloxacin and moxifloxacin in pulmonary tuberculosis

二维码有效期 120s

摘要目的:评估左氧氟沙星、加替沙星及莫西沙星等新氟喹诺酮类药物对肺结核患者的早期杀菌活性及延长早期杀菌活性.设计:随机开放临床试验.40例成年新诊断的涂阳肺结核患者(每组10例)分别每日单一接受异烟肼300mg,或左氧氟沙星1000mg,或加替沙星400mg,或莫西沙星400mg的7天治疗.治疗前2天及单药治疗7天期间,每日收集痰液进行定量培养.计量单药治疗开始的头2天(0-2天)及治疗后5天(2-7天)的菌量下降情况,以评估各药的早期及延长早期杀菌活性.对实验室工作人员关于病人治疗分组信息采用单盲法.结果:异烟肼的早期杀菌活性为0.67log10cfu/毫升/天,高于莫西沙星(0.33 log10cfu/毫升/天)及加替沙星(0.35 log10cfu/毫升/天).与每日1000mg左氧氟沙星的早期杀菌活性(0.45log10c叫毫升/天)相比,无统计学差异(P=0.14).3种氟喹诺酮类药物的早期杀菌活性(0-2天)与延长早期杀菌活性(2-7天)相似.总体说来,氟喹诺酮类药物的延长早期杀菌活性高于异烟肼.结论:莫西沙星、加替沙星及高剂量左氧氟沙星,虽然略低于异烟肼,但均有良好的早期杀菌活性,并具有较高的延长早期杀菌活性.有理由对这些药物敏感的结核病人进行进一步的治疗研究.

作者马玙 ^[1] J.L.Johnson ^[2] D.J.Hadad ^[1] W.H.Boom ^[3] C.L.Daley ^[4] C.A.Peloquin ^[5] K.D.Eisenach ^[1] D.D.Jankus ^[6] S.M.Debanne ^[7] E.D.Charlebois ^[2] E.Maciel ^[2] M.Palaci ^[2] R.Dietze 学术成果认领

作者单位 Department of Medicine, Division of Infectious Diseases, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio, USA ^[1] Núcleo de Doencas Infecciosas, Centro Biomédico,Universidade Federal cio Espirito Santo, Vitória, Brazil ^[2] Division of Mycobacterial and Respiratory Infections and, San Francisco, California, USA ^[3] Infectious Disease Pharmacokinetics Laboratory, National Jewish Medical and Research Center, Denver, San Francisco, California, USA;Schools of Pharmacy and Medicine, University of Colorado, Denver, Colorado, San Francisco, California, USA ^[4] University of Arkansas for Medical Sciences, Little Rock, Arkansas, San Francisco, California, USA ^[5] Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine,Cleveland, Ohio, San Francisco, California, USA ^[6] AIDS Research Institute, University of California-San Francisco, San Francisco, California, USA ^[7]

关键词结核,氟喹诺酮类药物莫西沙星左氧氟沙星加替沙星抗结核作用早期杀菌活性

医学主题词氧氟沙星(Ofloxacin)结核(Tuberculosis)药用制剂(Pharmaceutical Preparations)氟(Fluorine)喹诺酮类(Quinolones)

分类号 R9（药学）

栏目名称

原著

DOI 10.3969/j.issn.1006-6942.2006.02.002

发布时间 2006-11-08（万方平台首次上网日期，不代表论文的发表时间）