摘要目的：探讨软骨定量 MRI 新技术在骨关节炎诊断和治疗中的研究进展和应用前景。方法在 Medline 和 CNKI 数据库,分别以“Cartilage injury/ damage, osteoarthritis, T1ρmapping, Sodium MRI, magnetization transfer MRI, Chemical exchange saturation transfer, Ultrashort echo time MRI, DWI, DTI, Pharmacokinetic MRI”和“软骨损伤,骨关节炎,T1ρ值,钠磁共振成像,磁化传递磁共振成像,化学交换依赖性饱和传递技术,扩散加权成像,扩散张量成像,药物代谢动力学磁共振成像”为关键词,限定语言种类为 English 和中文,检索2001年1月—2014年7月间发表的有关软骨损伤和软骨定量MRI 研究的文章。就检索到的200余篇文献进行筛选,选择以软骨损伤和骨关节炎 MRI 的实验研究和临床研究为主要内容的文献86篇；其中研究相似的,以近5年且发表在较权威期刊者优先纳入分析。结果软骨的 MRI 和定量分析一直是学界研究热点之一,近年来随着 MRI 硬件和软件的提升,各种 MRI 新技术被应用于软骨 MRI 的定量分析,这些新技术在检测早期软骨损伤及软骨生化成分和血管成分的量化分析方面展示了良好的应用和研究前景,但是仍存在一些固有的缺陷。结论随着MR 硬件和软件的升级、新序列的开发与运用及理论研究的不断深入,这些新技术或可成为骨关节炎诊断和治疗的 MRI 生物标志物。

abstractsObjective To explore research progress and application prospects of new MRI technologies in diagnosis and treatment of osteoarthritis. Methods A computer-based online search of Medline database was undertaken to identify the articles about cartilage injury/ damage and cartilage quantitative MRI published in English from January 2004 to July 2014, with the key words of " Cartilage injury/ damage, osteoarthritis, T1ρmapping, Sodium MRI, magnetization transfer MRI, Chemical exchange saturation transfer, Ultrashort echo time MRI, DWI, DTI, Pharmacokinetic MRI" . And the computer-based online search of CNKI database was also undertaken to identify relevant articles published in Chinese from January 2004 to July 2014 with the key words of " 软骨损伤,骨关节炎,T1ρ 值,钠磁共振成像,磁化传递磁共振成像,化学交换±赖性?和传递技术,扩散加权成像,扩散张量成像,药物代谢动力学磁共振成像" . The first trial involved in 200 articles, and 86 articles of them referred to the experimental and clinical study of cartilage injury/ damage and osteoarthritis. In which those had similar content and published on authority magazines in recent 5 years were preferred. Results Cartilage MRI and quantitative analysis have been one of the hot-point academic researchs. In recent years, with the enhancement of MRI hardware and software, the new technology has been applied to cartilage quantitative MRI analysis. In terms of early detection of cartilage damage and cartilage biochemical composition and vascular components, quantitative analysis of these new MRI technologies showed good application and research prospects, but there were still some inherent flaws. Conclusions With MR hardware and software upgrades, the development and application of new MRI sequences and deepening of theoretical studies using these new technologies, parameter values derived these new quantitative MRI analysis techniques may become MRI biomarkers in diagnosis and treatment of osteoarthritis in the future.