摘要Hepatocellular carcinoma(HCC)is the second most lethal tumour,with therapies broadly divided into curative and palliative intent.Unfortunately,the majority of HCCs were found to be unresectable at diagnosis.Advances in novel loco-regional therapies have given patients with unresectable HCC a vital chance for disease control and survival.However,the COVID-19 pandemic has greatly shaped and impacted treatment protocols and delivery for HCC patients.This review article aims to describe the impact of the COVID-19 pandemic on the delivery of loco-regional treatment modalities for HCC and compare treatment trends between the pre-pandemic and pandemic eras.Treatment of HCC involves complex collaboration between clinical professionals within their local and global healthcare institutions.The COVID-19 pandemic has had a profound impact on the treatment of HCC.The delivery of loco-regional treatment for HCC will need to adapt to each healthcare system's unique structure.